Projects

List of project pages on this wiki.

Active Projects

• Developer Cell: A modular, extensible chassis for building synthetic cells (Alfred P. Sloan Foundation)
• Design and Implementation of Multi-Component Synthetic Cells (ARO/ICB)
• Control of Functional Bioenabled Materials using Synthetic Cells (ARO/ICB)
• Center for Harnessing Microbiota from Military Environments (CHARMME) (ARO)
• Layered T&E for Safety-Critical Autonomous Systems (AFOSR)
• Rules of Composition in Synthetic Biology Across Scales of Complexity: Theory and Tools (AFOSR)

Completed Projects

• Upscaling Engineering of Synthetic Biomachines (Schmidt Sciences)
• Safety-Critical Cyber-Physical Systems: From Validation & Verification to Test & Evaluation (NSF)
• Deciphering the Rules of Nucleus Architecture with Synthetic Cells and Organelles (NSF)
• Multi-Layer, Composable and Programmable Biomolecular Circuits for Microbial Consortia (Army Research Office)
• Engineering Reliable Genetic Circuits for Characterization and Remediation of Soil Ecologies (Army Research Office)
• Developing Standardized Cell-Free Platforms for Rapid Prototyping of Synthetic Biology Circuits and Pathways (NSF)
• Formal Methods for V&V and T&E of Autonomous Systems (AFOSR)
• Actuation of Synthetic Cells Via Proto-Flagellar Motors (NSF)
• An Open Synthetic Biology Toolkit for Engineering Reliable Genetic Circuits in Microbes in Soil (Resnick Sustainability Institute)
• Fundamental Biological Factors Underlying Human Performance: From Molecular Diagnostics and Detection to Behavior and Systems Biology (Army Research Office)
• Field-Programmable, Recombinase-Based Biomolecular Circuits (Army Research Office)
• Design of Digitally Controlled Bacterial Circuits for Bioenabled Materials (Army Research Lab/Institute for Collaborative Biotechnologies)
• VeHICaL: Verified Human Interfaces, Control, and Learning for Semi-Autonomous Systems (NSF)
• Engineering Replication-, Growth-, and Division-Deficient E. coli for Safe, Stable and Efficient Function (Rosen Center for Bioengineering)
• Assurance for Learning Enabled Systems (DARPA)
• Robust Multi-Layer Control Systems for Cooperative Cellular Behaviors (DARPA)
• Enabling Technologies for Cell-Silicon Interfacing (Army Research Office)
• Engineering Durable Cell-Free Biological Capabilities for Advanced Sensing and Prototyping (Army Research Office)
• Genetic Circuits for Multi-Cellular Machines (Army Research Lab/Institute for Collaborative Biotechnologies)
• Temporal Logic Specifications for Control System Design in Automotive Systems (DENSO)
• Theory-Based Engineering of Biomolecular Circuits in Living Cells (Air Force Office of Scientific Research)
• Biomolecular Circuits for Rapid Detection and Response to Environmental Events (Army Research Office)
• Molecular Programming Architectures, Abstractions, Algorithms, and Applications (NSF)
• Rapid, Reliable and Repeatable Platforms for Cell-Free Prototyping (Synvitrobio)
• Establishing microfluidic cell-free systems for the rapid prototyping of synthetic genetic networks (Human Frontiers Science Program)
• Safety-Critical Autonomy and Verification for Space Missions (JPL)
• Model-guided Discovery and Optimization of Cell-based Sensors (Office of Naval Research)
• The TerraSwarm Research Center (STARnet)
• Synthesizing flight software (FSW) discrete controllers from formal specifications (JPL)
• Programmable Molecular Technology Initiative (Gordon and Betty Moore Foundation)
• Cell-Free Expression of Membrane Proteins with Applications to Drug Discovery (Amgen)
• Resilient Risk-Aware Autonomy for the Exploration of Uncertain and Extreme Environments (Keck Institute for Space Studies)
• Improvement of E. coli transcription-translation (TX-TL) system (Caltech Grubstake)
• Correct-by-Construction Synthesis of Control Protocols for Aerospace Systems (Boeing)
• ICyPhy: Industrial Cyber-Physical Systems (IBM, UTC)
• Biomolecular Breadboards for Prototyping and Debugging Synthetic Biocircuits (DARPA)
• Molecular Programming Project (NSF)
• Biomolecular Feedback Circuits for Modular, Robust and Rapid Response (Army Research Office)
• Control Design for Cyberphysical Systems Using Slow Computing (NSF)
• Distributed Sense and Control Systems (DARPA FCRP)
• Network Science and Engineering: A Theory of Network Architecture (NSF)
• Networked Feedback Systems in Biology (ARO ICB)
• CAGEN: Critical Assessment of Genetically Engineered Networks (NAKFI)
• Model-Based Design and Qualification of Complex Systems (Boeing)
• Packet-Based Estimation and Control (AFOSR)

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• Biomolecular Breadboards for Prototyping and Debugging Synthetic Biocircuits (DARPA)
• Biomolecular Feedback Circuits for Modular, Robust and Rapid Response (ARO ICB)
• Molecular Programming Project (NSF)
• Networked Feedback Systems in Biology (ARO ICB)
• Distributed Sense and Control Systems (MuSyC)
• Control Design for Cyberphysical Systems Using Slow Computing (NSF)
• Network Science and Engineering: A Theory of Network Architecture (NSF)
• CAGEN: Critical Assessment of Genetically Engineered Networks (NAKFI)
• Model-Based Design and Qualification of Complex Systems (Boeing)
• Specification, Design and Verification of Distributed Embedded Systems (MURI/AFOSR)
• Information Dynamics for Networked Feedback Systems (NSF)
• 2007 DARPA Urban Challenge (DARPA; Caltech/JPL)
• Packet-Based Algorithms for Cooperative Surveillance and Reconnaissance (AFOSR)
• Control and Dynamical Systems Alliance (Dept of Education)
• Cooperative Control in Dynamic, Uncertain, and Adversarial Environments (MURI/AFOSR)
• DARPA Grand Challenge, Team Caltech (CIT)
• Information Flow in Cooperative Control of Multi-Vehicle Systems (AFOSR)
• High Confidence, Reconfigurable, Distributed Control (DARPA SEC)
• Mixed Initiative Control of Automa-Teams (DARPA MICA)
• Computationally Engineered Microstructural Complexity (MURI/ARO)
• Integrated Control of Inlet Compression Systems (DARPA MAFC)
• Panel on Future Directions in Control, Dynamics, and Systems
• Multi-Vehicle, Wireless Testbed (DURIP/AFOSR)
• Actively Stabilized Isentropic Supersonic Inlet (DARPA QSP)
• Formation Flight for Micro-Satellites (AFOSR)
• Virtual Integrated Processing of YBCO Thin Films (DARPA/NSF)
• Two Degree of Freedom Design for Robust Nonlinear Control of Mechanical Systems (NSF)
• Robust Nonlinear Control Theory with Application to Aerospace Vehicles (AFOSR)
• Robust Nonlinear Control of Stall and Flutter in Aeroengines (AFOSR)
• Nonlinear Control of Mechanical Systems in the Presence of Magnitude and Rate Saturations (ONR)
• Curriculum in Control and Dynamical Systems (NSF)