How to model DNA replication in stochastic models of synthetic genetic circuits (and why)
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| Title | How to model DNA replication in stochastic models of synthetic genetic circuits (and why) |
|---|---|
| Authors | Samuel E. Clamons and Richard M. Murray |
| Source | bioRxiv 2021.09.26.461880 |
| Abstract | Biocircuit modeling sometimes requires explicit tracking of a self-replicating DNA species. The most obvious, straightforward way to model a replicating DNA is structurally unstable and leads to pathological model behavior. We describe a simple, stable replication mechanism with good model behavior and show how to derive it from a mechanistic model of ColE1 replication. |
| Type | Preprint |
| URL | https://www.biorxiv.org/content/10.1101/2021.09.26.461880 |
| DOI | 10.1101/2021.09.26.461880 |
| Tag | cm21-biorxiv |
| ID | 2021n |
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