A 65nm CMOS Living-Cell Dynamic Fluorescence Sensor with 1.05fA Sensitivity at 600/700nm Wavelengths

Title	A 65nm CMOS Living-Cell Dynamic Fluorescence Sensor with 1.05fA Sensitivity at 600/700nm Wavelengths
Authors	Fatemeh Aghimand, Chelsea Hu, Saransh Sharma, Krishna K. Pochana, Richard M. Murray and Azita Emami
Source	2023 IEEE International Solid-State Circuits Conference (ISSCC)
Abstract	Integrated, low-cost and miniaturized devices that can detect clinically relevant biomarkers are crucial for the growing field of precision medicine as they can enable point-of-care diagnosis, continuous health monitoring and closed-loop drug delivery. Fluorescence (FL) sensing is known to be one of the most reliable, sensitive, and widely adopted sensing modality for many biomarkers. However, detecting the weak FL signal requires complex optical setups, especially narrowband optical filters to block the strong excitation (EX) light. Prior efforts to miniaturize and implement FL sensing in CMOS technologies have been limited to on-chip high-pass filters using dense vertical waveguide arrays. More importantly, the reported wavelength range of 800nm in prior work is not compatible with most of the commonly used fluorescent proteins that work with living cells. Luminescence is another mechanism for detecting biomarkers that does not require an EX source and optical filtering. However, there are limited number of luminescence proteins, and it is not feasible to use them in a closed-loop system since they can interfere with optogenetic control integration.
Type	Conference paper
URL	https://ieeexplore.ieee.org/abstract/document/10067325/authors#authors
DOI	10.1109/ISSCC42615.2023.10067325
Tag	Agh+23-ISSCC
ID	2023c
Funding	ARL Silicon-Cell
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