View source for Theoretical Design of Paradoxical Signaling-Based Synthetic Population Control Circuit in E. coli

{{Paper
|Title=Theoretical Design of Paradoxical Signaling-Based Synthetic Population Control Circuit in E. coli
|Authors=Michaëlle N. Mayalu, Richard M. Murray
|Source=2020 Winter q-bio
|Abstract=We have developed a mathematical framework to analyze the cooperative control of cell population homeostasis via paradoxical signaling in synthetic contexts. Paradoxical signaling functions through quorum sensing (where cells produce and release a chemical signal as a function of cell density). Precisely, the same quorum sensing signal provides both positive (proliferation) and negative (death) feedback in different signal concentration regimes. As a consequence, the relationship between intercellular quorum sensing signal concentration and net growth rate (cell proliferation minus death rates) can be non-monotonic. This relationship is a condition for robustness to certain cell mutational overgrowths and allows for increased stability in the presence of environmental perturbations. Here, we explore stability and robustness of a conceptualized synthetic circuit. Furthermore, we asses possible design principles that could exist among a subset of paradoxical circuit implementations. This analysis sparks the development a bio-molecular control theory to identify ideal underlying characteristics for paradoxical signaling control systems.
|URL=https://www.biorxiv.org/content/10.1101/2020.01.27.921734v1
|Type=Conference paper
|ID=2019i
|Tag=mm20-wqbio
|Funding=DARPA BioCon
|Flags=Biocircuits
}}