Systems Level Model of Dietary Effects on Cognition via the Microbiome-Gut-Brain Axis

From Murray Wiki
Revision as of 14:53, 15 September 2021 by Murray (talk | contribs) (Created page with "{{Paper |Title=Systems Level Model of Dietary Effects on Cognition via the Microbiome-Gut-Brain Axis |Authors=Michaëlle N. Mayalu, Anish Sarma, Fangzhou Xiao, John C. Doyle a...")
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigationJump to search
Title Systems Level Model of Dietary Effects on Cognition via the Microbiome-Gut-Brain Axis
Authors Michaëlle N. Mayalu, Anish Sarma, Fangzhou Xiao, John C. Doyle and Richard M. Murray
Source 2021 European Control Conference (ECC)
Abstract Intercommunication of the microbiome-gut-brain axis occurs through various signaling pathways including the vagus nerve, immune system, endocrine/paracrine, and bacteria-derived metabolites. But how these pathways integrate to influence cognition remains undefined. In this paper, we create a systems level mathematical framework comprised of interconnected organ-level dynamical subsystems to increase conceptual understanding of how these subsystems contribute to cognitive performance. With this framework we propose that control of hippocampal long-term potentiation (hypothesized to correlate with cognitive performance) is influenced by inter- organ signaling with diet as the external control input. Specifically, diet can influence synaptic strength (LTP) homeostatic conditions necessary for learning. The proposed model provides new qualitative information about the functional relationship between diet and output cognitive performance. The results can give insight for optimization of cognitive performance via diet in experimental animal models.
Type Conference paper
URL https://www.cds.caltech.edu/~murray/preprints/may+21-ecc.pdf
Tag may+21-ecc
ID 2020i
Funding GMB MURI
Flags