Difference between revisions of "Feedback architectures to regulate flux of components in artificial gene networks"

From Murray Wiki
Jump to navigationJump to search
(htdb2wiki: creating page for 2012t_gfm13-acc.html)
 
Line 5: Line 5:
| year = 2012
| year = 2012
| type = Conference Paper
| type = Conference Paper
| funding = MPP
| funding = MPP2
| url = http://www.cds.caltech.edu/~murray/preprints/gfm13-acc_s.pdf
| url = http://www.cds.caltech.edu/~murray/preprints/gfm13-acc_s.pdf
| abstract =  
| abstract =  

Revision as of 21:03, 11 June 2016


Giulia Giordano, Elisa Franco and Richard M. Murray
Submitted, 2013 American Control Conference (ACC)

This paper focuses on RNA flux regulation for in vitro synthetic gene networks and considers architectures that can be scaled to an arbitrary number of species. Feedback loops are designed based on negative autoâregulation (which can minimize the potentially harmful amount of molecules not used to form useful products) and crossâactivation (which can maximize the overall output flux): transcription rate matching can be achieved through proper feedback constants; negative feedback is faster and maintains stability. A possible experimen- tal implementation of a three and four genes negative feedback architecture is also numerically studied.