Difference between revisions of "CAGEN: Critical Assessment of Genetically Engineered Networks"

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The Competitive Assessment for Genetically Engineered Networks
The Critical Assessment for Genetically Engineered Networks (CAGEN) is a competition intended to drive new approaches to designing robust, synthetic biological circuits.  The competition involves teams of established researchers designing circuits that implement a given function and the assessment of their circuit's performance across a set of multiple operating environments.  More information is available on the  [[http:www.openwetware.org/wiki/CAGEN|CAGEN web site]] (on OpenWetWare). __NOTOC__
(CAGEN) is a competition intended to drive new approaches to
designing robust, synthetic biological circuits.  The competition
involves teams of established researchers designing circuits that
implement a given function and the assessment of their circuit's
performance across a set of multiple operating environments.  __NOTOC__


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Current participants:
Current participants:
* {{Clarmyra Hayes}}
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Previous participants:
Previous participants:
* {{Shaunak Sen}}
|}
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counterparts.
counterparts.


== Tentative timeline ==
== Publications ==
{{agenda begin}}
* {{sm12-cdc}}
{{agenda item|Jul 2010|First steering committee meeting; selection of draft competition specifications}}
{{agenda item|Nov 2010|Refinement of specifications completed; call for participation released}}
{{agenda item|Jan 2011|Proposals for team funding/resources due}}
{{agenda item|Feb 2011|Selection of proposals for support}}
{{agenda item|Nov 2011|Submission deadline and selection of finalists}}
{{agenda item|Jun 2012|Workshop for finalists; competition results announced}}
{{agenda end}}


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[[Category:Completed projects]]
== Publications ==
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Latest revision as of 02:37, 26 November 2015

The Critical Assessment for Genetically Engineered Networks (CAGEN) is a competition intended to drive new approaches to designing robust, synthetic biological circuits. The competition involves teams of established researchers designing circuits that implement a given function and the assessment of their circuit's performance across a set of multiple operating environments. More information is available on the CAGEN web site (on OpenWetWare).

Current participants:

  • Clarmyra Hayes (research technician)

Previous participants:

  • Shaunak Sen (postdoc, CDS)

Project Overview

We propose to develop and prototype a new competition designed to improve the robustness and performance of human-designed biological circuits and devices operating in cells. The Competitive Assessment for Genetically Engineered Networks (CAGEN, pronounced "cajun") will bring together leading research groups in biological circuit design to compete to demonstrate their abilities at designing circuits that perform in a prescribed manner in a variety of cellular contexts. Each year, a steering committee will propose a challenge problem that involves the design of an increasingly complex set of biological functions in a range of environments. Teams must submit their sequences, plasmid DNA implementing their circuit and data characterizing the performance of their system against a specified test suite. The top 3-5 designs will be submitted to the NSF BIOFAB (run by Adam Arkin and Drew Endy) for final characterization, and the winner will be selected based on a set of quantifiable metrics.

As part of this proposal, we plan to implement one iteration of the competition, including selecting the challenge problem, implementing a set of reference test protocols, announcing and publicizing the competition, implementing the selection process and choosing a winner. If successful, we believe that the competition can be proposed for continued funding from other sources and that over the medium term (5-10 years) CAGEN could lead toward a more robust set of biological design methods that allow human-designed circuits and devices to perform at levels closer to their biological counterparts.

Publications