Assessment of Robustness to Temperature in a Negative Feedback Loop and a Feedforward Loop

From Murray Wiki
Revision as of 02:26, 15 July 2021 by Murray (talk | contribs) (Created page with "{{Paper |Title=Assessment of Robustness to Temperature in a Negative Feedback Loop and a Feedforward Loop |Authors=Abhilash Patel, Richard M Murray, Shaunak Sen |Source=ACS Sy...")
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigationJump to search
Title Assessment of Robustness to Temperature in a Negative Feedback Loop and a Feedforward Loop
Authors Abhilash Patel, Richard M Murray, Shaunak Sen
Source ACS Synthetic Biology, 9(7):1581-1590, 2020
Abstract Robustness to temperature variation is an important specification in biomolecular circuit design. While the cancellation of parametric temperature dependencies has been shown to improve the temperature robustness of the period in a synthetic oscillator design, the performance of other biomolecular circuit designs in different temperature conditions is relatively unclear. Using a combination of experimental measurements and mathematical models, we assessed the temperature robustness of two biomolecular circuit motifs—a negative feedback loop and a feedforward loop. We found that the measured responses of both the circuits changed with temperature, both in the amplitude and in the transient response. We also found that, in addition to the cancellation of parametric temperature dependencies, certain parameter regimes could facilitate the temperature robustness of the negative feedback loop, although at a performance cost. We discuss these parameter regimes in the context of the measured data for the negative feedback loop. These results should help develop a framework for assessing and designing temperature robustness in biomolecular circuits.
Type Journal paper
URL https://pubs.acs.org/doi/abs/10.1021/acssynbio.0c00023
Tag PMS20-ACSsynbio
ID 2020b
Funding
Flags