Rapid, Reliable and Repeatable Platforms for Cell-Free Prototyping: Difference between revisions
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* Zachary Sun, Abel Chiao (Synvitrobio, Inc.) | |||
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Revision as of 04:29, 17 April 2017
We are working with Synvitrobio, Inc. to develop and commercialize a cell-free platform that that emulates the in vivo environment and allows for rapid, low-cost, high-throughput, and reproducible prototyping of complex biomolecular networks. Achieving this goal will accelerate predictive and rational engineering of biology by providing an intermediary environment between design and execution.
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Objectives
Work at Caltech is focused on the following areas:
- Reduce variability of output data from the cell-free experts by analyzing sources of variability and developing methods of calibrating cell-free data sets
- Explore the use of lyophilized extracts and buffers for long-term storage.
References
- A MATLAB toolbox for modeling genetic circuits in cell-free systems. Vipul Singhal, Zoltan A. Tuza, Zachary Z. Sun, Richard M. Murray. Synthetic Biology, 6(1):ysab007, 2021.
- Cell-Free Extract Data Variability Reduction in the Presence of Structural Non-Identifiability. Vipul Singhal and Richard M. Murray. Submitted, 2019 American Control Conference (ACC).
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