Networked Feedback Systems in Biology

This is a joint project with John Doyle, funded by the ARO Institute for Collaborative Biotechnology. This page primarily describes the work done in Richard Murray's group.

Current participants: Dionysios Barmpoutis (PhD student, CNS) Elisa Franco (PhD student, CDS) Ben Prindle Ophelia Venturelli (PhD student, BMB)

Previous participants: Mary Dunlop Per-Ola Forsberg Roman Galeev Henrik Sandberg Johan Ugander Kevin Welch

Objectives

We are developing a theoretical foundation for a network science relevant to the understanding and design of complex "systems of systems" typified by biological networks. We are particularly focusing on the organizational principles underlying their ``robust yet fragile aspects, scalability, and evolvability, and demonstrating progress with case studies of varying detail using familiar and concrete examples from biological networks and network-centric technologies. Biological examples will focus on intracellular regulatory networks and intercellular communication.

Publications

• E. Franco, P. O. Forsberg and R. M. Murray. "Design, modeling and synthesis of an in vitro transcription rate regulatory circuit" Submitted to American Control Conference 2008.
• M. J. Dunlop, E. Franco, R. M. Murray. "A Multi-Model Approach to Identification of Biosynthetic Pathways." In Proceedings of the 26th American Control Conference 2007.
• J. Ugander, M. J. Dunlop, R. M. Murray. "Analysis of a Digital Clock for Molecular Computing." In Proceedings of the 26th American Control Conference 2007.

Miscellaneous

• BioControl Journal Club