Networked Feedback Systems in Biology

This is a joint project with John Doyle, funded by the ARO Institute for Collaborative Biotechnology. This page primarily describes the work done in Richard Murray's group.

width=50% Current participants: Mary Dunlop Elisa Franco (PhD student, CDS)

Previous participants: Per-Ola Forsberg Roman Galeev Henrik Sandberg Johan Ugander

Objectives

We are developing a theoretical foundation for a network science relevant to the understanding and design of complex "systems of systems" typified by biological networks. We are particularly focusing on the organizational principles underlying their ``robust yet fragile aspects, scalability, and evolvability, and demonstrating progress with case studies of varying detail using familiar and concrete examples from biological networks and network-centric technologies. Biological examples will focus on intracellular regulatory networks and intercellular communication.

Publications

• Towards Biological System Identification: Fast and Accurate Estimates of Parameters in Genetic Regulatory Networks, Mary J. Dunlop and Richard M. Murray. Submitted, 2006 Conference on Decision and Control.