Networked Feedback Systems in Biology
We are developing a theoretical foundation for a network science relevant to the understanding and design of complex "systems of systems" typified both by biological networks and by the Army's Future Combat Systems (FCS). We are particularly focusing on the organizational principles underlying their ``robust yet fragile aspects, scalability, and evolvability, and demonstrating progress with case studies of varying detail using familiar and concrete examples from biological networks and network-centric technologies. Biological examples will focus on intracellular regulatory networks, intercellular communication, primarily in microbes and particularly with relevance to pathogenesis.
- Towards Biological System Identification: Fast and Accurate Estimates of Parameters in Genetic Regulatory Networks, Mary J. Dunlop and Richard M. Murray. Submitted, 2006 Conference on Decision and Control.