Edit Project: Field-Programmable, Recombinase-Based Biomolecular Circuits

Project description: {{righttoc}} This project funded by the [http://www.icb.ucsb.edu/ Army's Institute for Collaborative Biotechnologies], an Army University Affiliated Research Center (UARC) {| cellpadding=0 cellspacing=0 width=80% |- valign=top | Current participants: {{project current participants}} Additional participants: {{project additional participants}} | Collaborators: Past participants: {{project past participants}} |} === Objectives === [[Image:aicb19-fieldprogrammable.png|right|400px]] This project explores the use of recombinases -- integrases, excisionases, and other methods of manipulating DNA -- as platform for engineering biomolecular circuits. Our high-level goal is to develop a design-oriented framework for recombinase-based, genetically-encoded circuits that can be used for detection, diagnostics, and logging of environmental signals and events. The specific objectives this project are to: * Develop circuit components, mathematical models, experimental protocols, and system characterization methods that enable recombinase-based circuits to be designed and utilized in a systematic fashion. * Implement a set of biological “event detectors” in both cell-free and cell-based assays, and demonstrate their utility in applications that combine digital, analog, and stochastic operations. === References === {{project paper list}} [[Category:Completed projects]] [[Category:Biocircuits projects]]

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