View source for Feedback architectures to regulate flux of components in artificial gene networks

{{HTDB paper
| authors = Giulia Giordano, Elisa Franco and Richard M. Murray
| title = Feedback architectures to regulate flux of components in artificial gene networks
| source = Submitted, 2013 American Control Conference (ACC)
| year = 2012
| type = Conference Paper
| funding = MPP
| url = http://www.cds.caltech.edu/~murray/preprints/gfm13-acc_s.pdf
| abstract = 
This paper focuses on RNA flux regulation for in vitro synthetic gene networks and considers architectures that can be scaled to an arbitrary number of species. Feedback loops are designed based on negative autoâregulation (which can minimize the potentially harmful amount of molecules not used to form useful products) and crossâactivation (which can maximize the overall output flux): transcription rate matching can be achieved through proper feedback constants; negative feedback is faster and maintains stability. A possible experimen- tal implementation of a three and four genes negative feedback architecture is also numerically studied.
| flags = 
| filetype = PDF
| filesize = 1816K
| tag = gfm13-acc
| id = 2012t
}}