Edit Project: Enabling Technologies for Cell-Silicon Interfacing

Project description: {{righttoc}} This project focuses on the challenges faced by traditional detection and diagnostic technologies including shelf-life, signal amplification and sensitivity, continuous monitoring and device lifetime, detection range, and matrix compatibility. Further, it provides the enabling technology to expand functionality in computation and biochemical response for mixed-mode sensing devices. {| cellpadding=0 cellspacing=0 width=80% |- valign=top | Current participants: {{project current participants}} Additional participants: {{project additional participants}} | Collaborators: * Azita Emami (Caltech EE) Past participants: {{project past participants}} |} === Objectives === [[Image:arl19-hybrid.png|right|500px]] The general objective is to develop the fundamental technologies required for cell-CMOS interfacing by demonstrating a proof-of-concept, mixed-mode sensing device that can sense and transduce signals from a complex matrix. Specific objectives: # Engineer and validate an arsenic-sensing circuit into Bacillus megaterium. # Fabricate the microfluidics necessary for the retention of biological sensors to the IC # Develop the CMOSIC technology, integrate it with the biological sensors and demonstrate the proof-of-concept for a mixed-mode sensing device # Expand the capability of CMOSIC and cell-based circuits to enable communication from silicon to the cell, enabling programmability of cell-based circuits from ICs. === References === {{project paper list}} [[Category:Completed projects]] [[Category:Biocircuits projects]]

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