View source for Biomolecular resource utilization in elementary cell-free gene circuits

{{HTDB paper
| authors = Dan Siegal-Gaskins, Vincent Noireaux, and Richard M. Murray
| title = Biomolecular resource utilization in elementary cell-free gene circuits
| source = 2013 American Control Conference (ACC)
| year = 2012
| type = Conference Paper
| funding = DARPA LF
| url = http://www.cds.caltech.edu/~murray/preprints/snm13-acc.pdf
| abstract = 
We present a detailed dynamical model of the behavior of
transcription-translation circuits in vitro that makes explicit the roles
played by essential molecular resources. A set of simple two-gene test
circuits operating in a cell-free biochemical âbreadboardâ validate this
model and highlight the consequences of limited resource availability. In
particular, we are able to confirm the existence of biomolecular âcrosstalkâ
and isolate its individual sources. The implications of crosstalk for
biomolecular circuit design and function are discussed.
| flags = 
| filetype = PDF
| filesize = 368K
| tag = snm13-acc
| id = 2012p
}}