NIH P50

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Center for Biological Systems Architecture (CBSA)

Christina D. Smolke (PI)
Anand Asthagiri      David Baltimore      John Doyle      Michael Elowitz
Grant Jensen      Richard Murray      Dianne Newman      Rob Phillips

Goals

  • To develop a complete and predictive understanding of the control systems that are responsible for core processes of metabolism, polymerization, assembly and signal transduction in microorganisms
  • To apply the techniques developed through the study of individual cells to the complementary problems of communication modes and probabilistic decision processes in multi-cellular systems
  • To develop a complete and predictive understanding of the control systems that are responsible for regulating the processes directing how mammalian cells interact with their environment.

Timeline

  • 16-18 Nov: CDS out of town (online)
  • 19 Nov (Sun): Meet at 10 am in Steele

Proposal Outline

Program summary (5 pages)

Organizational structure/decision making plan (2 pages)

Center development and outreach plans (5 pages)

Research projects and preliminary studies (50 pages)

DBP #1
DBP #2
DBP #3
Experimental Platforms
Theory and Computation

Core facilities (2 pages)

Intellectual property plan (1 page)

Diversity (URM) plan (1 page)

Timeline (2 pages)