Field-Programmable, Recombinase-Based Biomolecular Circuits

Project description (typically about a paragraph)

Current participants: Additional participants:

Collaborators: Past participants: John Marken (Alumni, BE) Joe Meyerowitz (Alumni, BMB) Andrey Shur (Alumni, BE) Rory Williams (Alumni, BE)

Objectives

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Description of the main objectives of the project

References

• Addressable and adaptable intercellular communication via DNA messaging. John P. Marken and Richard M. Murray. Nature Communications, 14:2358, 2023.
• Integrase-mediated differentiation circuits improve evolutionary stability of burdensome and toxic functions in E. coli. Rory L. Williams and Richard M. Murray. Nature Communications, 13:6822, 2022.
• Tunable integrase-mediated differentiation facilitates improved output of burdensome functions in E. coli. Rory L. Williams, Richard M. Murray. bioRxiv 614529, 2019 (revised 2020, 2022).
• Addressable, “Packet-Based” Intercellular Communication through Plasmid Conjugation. John P. Marken, Richard M. Murray. qBio 2019 Conference.
• Proof of concept continuous event logging in living cells. Andrey Shur, Richard M. Murray. 2019 Synthetic Biology: Engineering, Evolution and Design (SEED) Conference.

Agency: Army Research Office Grant number: ICB-2019-SSB-02-Murray

Start date: 1 Dec 2018 End date: 30 Nov 2021

Support: 1 graduate student, part-time technician Reporting: Annual reports