NIH P50

Center for Biological Systems Architecture (CBSA)

Christina D. Smolke (PI)
Anand Asthagiri      David Baltimore      John Doyle      Michael Elowitz
Grant Jensen      Richard Murray      Dianne Newman      Rob Phillips

Goals To develop a complete and predictive understanding of the control systems that are responsible for core processes of metabolism, polymerization, assembly and signal transduction in microorganisms To apply the techniques developed through the study of individual cells to the complementary problems of communication modes and probabilistic decision processes in multi-cellular systems To develop a complete and predictive understanding of the control systems that are responsible for regulating the processes directing how mammalian cells interact with their environment.

Timeline 16-18 Nov: CDS out of town (online) 19 Nov (Sun): Meet at 10 am in Steele

Proposal Outline

Program summary (5 pages)

• Current owner: Richard
• Sent out for comment on 13 Nov
• Added paragraph from MBE in single cell imaging

Organizational structure/decision making plan (2 pages)

• Current owner: Richard
• Working on first iteration; sent to Christina then to group

Center development and outreach plans (5 pages)

• Current owner: Richard
• Sent out for comment

Education and Training

• Owner: Richard Murray
• Initial version sent out for comment