Fundamental Biological Factors Underlying Human Performance: From Molecular Diagnostics and Detection to Behavior and Systems Biology

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In collaboration with researchers at MIT (Lauffenburger) and ERDC (Perkins, Vinas) we are using zebrafish as a model organism for studying gut microbiome-brain interactions, with a focus on how the chemistry of the gut microbiome affects organism behavior, including sleep patterns and stress. Zebrafish provide an outstanding platform due to their maturity as a model organism as well as their transparent state as an embryo, allowing imaging of gut microbes and other biological features.

Current participants:

  • Samuel Clamons (PhD student, BE)
  • Mark Prator (Technician, EAS)

Additional participants:

  • Andrey Shur (PhD student, BE)


Past participants:



Caltech's portion of the project focuses on two primary tasks:

  1. The influence of gut microbiome on brain function: Diagnostics and logging of microbiotic environments in organisms
  2. The influence of gut microbiome/brain interactions on the systems biology of performance


  • Agency: Army Research Laboratory
  • Grant number:
  • Start date: 1 Jan 2019
  • End date: 30 Dec 2021
  • Support: 1 postdoc, 2 graduate students, research technician
  • Reporting: