Fundamental Biological Factors Underlying Human Performance: From Molecular Diagnostics and Detection to Behavior and Systems Biology
In collaboration with researchers at MIT (Lauffenburger) and ERDC (Perkins, Vinas) we are using zebrafish as a model organism for studying gut microbiome-brain interactions, with a focus on how the chemistry of the gut microbiome affects organism behavior, including sleep patterns and stress. Zebrafish provide an outstanding platform due to their maturity as a model organism as well as their transparent state as an embryo, allowing imaging of gut microbes and other biological features.
Caltech's portion of the project focuses on two primary tasks:
- The influence of gut microbiome on brain function: Diagnostics and logging of microbiotic environments in organisms
- The influence of gut microbiome/brain interactions on the systems biology of performance
- Analysis of Circuits for Dosage Control in Microbial Populations (Sophie J Walton, Samuel E Clamons, Richard M Murray, Senior thesis)