Upscaling Engineering of Synthetic Biomachines - Revision history

Murray at 06:07, 7 December 2025

2025-12-07T06:07:02Z

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	{\| cellpadding=0 cellspacing=0 width=80%		{\| cellpadding=0 cellspacing=0 width=80%
	\|- valign=top		\|- valign=top
	\|		\| Project participants:
	Project participants:
	* [[http:bnext.bio\|b.next]]		* [[http:bnext.bio\|b.next]]
	{{project past participants}}		{{project past participants}}

Murray at 06:06, 7 December 2025

2025-12-07T06:06:39Z

← Older revision		Revision as of 06:06, 7 December 2025
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	\|- valign=top		\|- valign=top
	\|		\|
	~~Current~~ participants:		Project participants:
	* [[http:bnext.bio\|b.next]]		* [[http:bnext.bio\|b.next]]
	~~Additional participants:~~		{{project past participants}}
	{{project ~~additional~~ participants}}		\| Collaborators (Steering Committee):
	\|
	Collaborators (Steering Committee):
	* Drew Endy (Stanford)		* Drew Endy (Stanford)
	* Paul Freemont (Imperial)		* Paul Freemont (Imperial)
	* Elizabeth Strychalski/Jane Romantseva (NIST)		* Elizabeth Strychalski/Jane Romantseva (NIST)

	~~Past participants:~~
	~~{{project past participants}}~~
	\|}		\|}

Murray at 04:51, 6 January 2025

2025-01-06T04:51:19Z

← Older revision		Revision as of 04:51, 6 January 2025
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	{{project paper list}}		{{project paper list}}

	[[Category:~~Active projects]]~~		[[Category:Completed projects]]
	~~[[Category:Biocircuits~~ projects]]
	{{Project		{{Project
	\|Title=Upscaling Engineering of Synthetic Biomachines		\|Title=Upscaling Engineering of Synthetic Biomachines
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	\|Grant number=2023-3-2-1		\|Grant number=2023-3-2-1
	\|Start date=1 Apr 2023		\|Start date=1 Apr 2023
	\|End date=~~30 Sep~~ 2024		\|End date=31 Dec 2024
	\|Support summary=3 full-time research engineers		\|Support summary=3 full-time research engineers
	\|Reporting requirements=Interim and final report		\|Reporting requirements=Interim and final report

Murray at 21:29, 10 August 2024

2024-08-10T21:29:15Z

← Older revision		Revision as of 21:29, 10 August 2024
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	{{Project		{{Project
	\|Title=Upscaling Engineering of Synthetic Biomachines		\|Title=Upscaling Engineering of Synthetic Biomachines
	\|Agency=Schmidt ~~Futures~~		\|Agency=Schmidt Sciences
	\|Grant number=2023-3-2-1		\|Grant number=2023-3-2-1
	\|Start date=1 Apr 2023		\|Start date=1 Apr 2023

Murray at 00:52, 10 July 2023

2023-07-10T00:52:06Z

← Older revision		Revision as of 00:52, 10 July 2023
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	[[Category:Active projects]]		[[Category:Active projects]]
	[[Category:Biocircuits projects]]		[[Category:Biocircuits projects]]

	{{Project		{{Project
	\|Title=Upscaling Engineering of Synthetic Biomachines		\|Title=Upscaling Engineering of Synthetic Biomachines
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	\|End date=30 Sep 2024		\|End date=30 Sep 2024
	\|Support summary=3 full-time research engineers		\|Support summary=3 full-time research engineers
			\|Reporting requirements=Interim and final report
	\|Project ID=Schmidt SynCell		\|Project ID=Schmidt SynCell
	\|ack=This project is funded through Schmidt Futures.		\|ack=This project is funded through Schmidt Futures.
	}}		}}

Murray: /* References */

2023-07-10T00:51:27Z

References

← Older revision		Revision as of 00:51, 10 July 2023
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	[[Category:Biocircuits projects]]		[[Category:Biocircuits projects]]

	~~{{{Template:project boilerplate}}}~~
	{{Project		{{Project
	\|Title=Upscaling Engineering of Synthetic Biomachines		\|Title=Upscaling Engineering of Synthetic Biomachines

Murray at 00:42, 10 July 2023

2023-07-10T00:42:49Z

← Older revision		Revision as of 00:42, 10 July 2023
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	\|		\|
	Current participants:		Current participants:
	~~{{project current participants}}~~		* [[http:bnext.bio\|b.next]]
	Additional participants:		Additional participants:
	{{project additional participants}}		{{project additional participants}}
	\|		\|
	Collaborators:		Collaborators (Steering Committee):
			* Drew Endy (Stanford)
			* Paul Freemont (Imperial)
			* Elizabeth Strychalski/Jane Romantseva (NIST)

	Past participants:		Past participants:
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	=== Objectives ===		=== Objectives ===
	[[Image:~~project~~-~~name~~.png\|right\|400px]]		[[Image:schmidt-syncell.png\|right\|400px]]
	~~Description~~ of the ~~main~~ objectives of ~~the~~ project		The goal of this project is to demonstrate a new model for biological systems engineering that can serve as a starting point for a larger effort in systems engineering of biological systems. We will focus on proof- of-concept demonstrations in synthetic cells, a class of non-living biological machines, constructed from biological components such as lipids, amino acids, proteins, and DNA. Synthetic cells do not mutate or evolve, allowing more systematic and repeatable engineering, and also providing significant advantages in environments where it may not be desirable to deploy genetically engineered organisms. We anticipate that the methods we develop can also serve as a testbed for engineering methods in living organisms.

			Specific objectives:
			* M0: Recruit lead engineer, project team, and steering committee
			* M1: Define demonstration project, components/partners, and required tools
			* Iterative engineering of demonstration project and release of open-Source artifacts
			** M2, 31 Dec 2023: initial attempt at integration + initial release of open source artifacts
			** M3, 31 Mar 2023: second iteration/release + proposal for Phase II activities, funding
			** M4, 30 Jun 2023: third iteration/release; stop or proceed to Phase II
			** M5, 30 Sep 2024: successful transition to FRO or other model for continued activity

	=== References ===		=== References ===

Murray at 00:36, 10 July 2023

2023-07-10T00:36:34Z

← Older revision		Revision as of 00:36, 10 July 2023
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			{{righttoc}}
	The long-term goal of this research activity is to formulate, demonstrate, and evaluate a new model for biological systems engineering. To develop and demonstrate this approach, a team of research engineers will integrate components and circuits created by others to implement a non-trivial biological function. The demonstration will include standardizing components and chasses, “routinizing” the required workflows, and systematizing the design abstractions and tools. This project is an 18-month seed effort focused on proof-of-concept integration in synthetic cells that would yield a novel, multicomponent “biomachine”, while generating and disseminating a set of component standards, design abstractions, software tools, laboratory protocols, and open-source artifacts (hardware, software, wetware) to the community.		The long-term goal of this research activity is to formulate, demonstrate, and evaluate a new model for biological systems engineering. To develop and demonstrate this approach, a team of research engineers will integrate components and circuits created by others to implement a non-trivial biological function. The demonstration will include standardizing components and chasses, “routinizing” the required workflows, and systematizing the design abstractions and tools. This project is an 18-month seed effort focused on proof-of-concept integration in synthetic cells that would yield a novel, multicomponent “biomachine”, while generating and disseminating a set of component standards, design abstractions, software tools, laboratory protocols, and open-source artifacts (hardware, software, wetware) to the community.

			{\| cellpadding=0 cellspacing=0 width=80%
			\|- valign=top
			\|
			Current participants:
			{{project current participants}}
			Additional participants:
			{{project additional participants}}
			\|
			Collaborators:

			Past participants:
			{{project past participants}}
			\|}

			=== Objectives ===
			[[Image:project-name.png\|right\|400px]]
			Description of the main objectives of the project

			=== References ===
			{{project paper list}}

			[[Category:Active projects]]
			[[Category:Biocircuits projects]]

	{{{Template:project boilerplate}}}		{{{Template:project boilerplate}}}

Murray at 00:35, 10 July 2023

2023-07-10T00:35:04Z

← Older revision		Revision as of 00:35, 10 July 2023
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	The long-term goal of this research activity is to formulate, demonstrate, and evaluate a new model for biological systems engineering. To develop and demonstrate this approach, a team of research engineers will integrate components and circuits created by others to implement a non-trivial biological function. The demonstration will include standardizing components and chasses, “routinizing” the required workflows, and systematizing the design abstractions and tools. This project is an 18-month seed effort focused on proof-of-concept integration in synthetic cells that would yield a novel, multicomponent “biomachine”, while generating and disseminating a set of component standards, design abstractions, software tools, laboratory protocols, and open-source artifacts (hardware, software, wetware) to the community.		The long-term goal of this research activity is to formulate, demonstrate, and evaluate a new model for biological systems engineering. To develop and demonstrate this approach, a team of research engineers will integrate components and circuits created by others to implement a non-trivial biological function. The demonstration will include standardizing components and chasses, “routinizing” the required workflows, and systematizing the design abstractions and tools. This project is an 18-month seed effort focused on proof-of-concept integration in synthetic cells that would yield a novel, multicomponent “biomachine”, while generating and disseminating a set of component standards, design abstractions, software tools, laboratory protocols, and open-source artifacts (hardware, software, wetware) to the community.

	{{{project boilerplate}}}		{{{Template:project boilerplate}}}

	{{Project		{{Project
	\|Title=Upscaling Engineering of Synthetic Biomachines		\|Title=Upscaling Engineering of Synthetic Biomachines

Murray at 00:34, 10 July 2023

2023-07-10T00:34:53Z

← Older revision		Revision as of 00:34, 10 July 2023
Line 1:		Line 1:
	The long-term goal of this research activity is to formulate, demonstrate, and evaluate a new model for biological systems engineering. To develop and demonstrate this approach, a team of research engineers will integrate components and circuits created by others to implement a non-trivial biological function. The demonstration will include standardizing components and chasses, “routinizing” the required workflows, and systematizing the design abstractions and tools. This project is an 18-month seed effort focused on proof-of-concept integration in synthetic cells that would yield a novel, multicomponent “biomachine”, while generating and disseminating a set of component standards, design abstractions, software tools, laboratory protocols, and open-source artifacts (hardware, software, wetware) to the community.		The long-term goal of this research activity is to formulate, demonstrate, and evaluate a new model for biological systems engineering. To develop and demonstrate this approach, a team of research engineers will integrate components and circuits created by others to implement a non-trivial biological function. The demonstration will include standardizing components and chasses, “routinizing” the required workflows, and systematizing the design abstractions and tools. This project is an 18-month seed effort focused on proof-of-concept integration in synthetic cells that would yield a novel, multicomponent “biomachine”, while generating and disseminating a set of component standards, design abstractions, software tools, laboratory protocols, and open-source artifacts (hardware, software, wetware) to the community.

	{{{project ~~template~~}}}		{{{project boilerplate}}}

	{{Project		{{Project
	\|Title=Upscaling Engineering of Synthetic Biomachines		\|Title=Upscaling Engineering of Synthetic Biomachines