Guidelines for Designing the Antithetic Feedback Motif - Revision history

Murray: Murray moved page Design Guidelines For Sequestration Feedback Networks to Guidelines for Designing the Antithetic Feedback Motif

2022-09-26T04:30:32Z

Murray moved page Design Guidelines For Sequestration Feedback Networks to Guidelines for Designing the Antithetic Feedback Motif

← Older revision		Revision as of 04:30, 26 September 2022
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Murray at 04:30, 26 September 2022

2022-09-26T04:30:12Z

← Older revision		Revision as of 04:30, 26 September 2022
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	{{Paper		{{Paper
	\|Title=~~Design~~ Guidelines ~~For Sequestration~~ Feedback ~~Networks~~		\|Title=Guidelines for Designing the Antithetic Feedback Motif
	\|Authors=Ania-Ariadna Baetica, Yoke Peng Leong~~, Noah Olsman~~, Richard M. Murray		\|Authors=Ania-Ariadna Baetica, Yoke Peng Leong, Richard M. Murray
	\|Source=Physical Biology, 17(5):055002, 2020		\|Source=Physical Biology, 17(5):055002, 2020
	\|Abstract=Integral control is commonly used in mechanical and electrical systems to ensure perfect adaptation. A proposed design of integral control for synthetic biological systems employs the sequestration of two biochemical controller species. The unbound amount of controller species captures the integral of the error between the current and the desired state of the system. However, implementing integral control inside bacterial cells using sequestration feedback has been challenging due to the controller molecules being degraded and diluted. Furthermore, integral control can only be achieved under stability conditions that not all sequestration feedback networks fulfill. In this work, we give guidelines for ensuring stability and good performance (small steady-state error) in sequestration feedback networks. Our guidelines provide simple tuning options to obtain a flexible and practical biological implementation of sequestration feedback control. Using tools and metrics from control theory, we pave the path for the systematic design of synthetic biological systems.		\|Abstract=Integral control is commonly used in mechanical and electrical systems to ensure perfect adaptation. A proposed design of integral control for synthetic biological systems employs the sequestration of two biochemical controller species. The unbound amount of controller species captures the integral of the error between the current and the desired state of the system. However, implementing integral control inside bacterial cells using sequestration feedback has been challenging due to the controller molecules being degraded and diluted. Furthermore, integral control can only be achieved under stability conditions that not all sequestration feedback networks fulfill. In this work, we give guidelines for ensuring stability and good performance (small steady-state error) in sequestration feedback networks. Our guidelines provide simple tuning options to obtain a flexible and practical biological implementation of sequestration feedback control. Using tools and metrics from control theory, we pave the path for the systematic design of synthetic biological systems.

Murray at 20:02, 4 September 2021

2021-09-04T20:02:01Z

← Older revision		Revision as of 20:02, 4 September 2021
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	\|Title=Design Guidelines For Sequestration Feedback Networks		\|Title=Design Guidelines For Sequestration Feedback Networks
	\|Authors=Ania-Ariadna Baetica, Yoke Peng Leong, Noah Olsman, Richard M. Murray		\|Authors=Ania-Ariadna Baetica, Yoke Peng Leong, Noah Olsman, Richard M. Murray
	\|Source=~~Submitted~~, ~~<i>Cell Systems</i>~~ (~~Nov 2018~~)		\|Source=Physical Biology, 17(5):055002, 2020
	\|Abstract=Integral control is commonly used in mechanical and electrical systems to ensure perfect adaptation. A proposed design of integral control for synthetic biological systems employs the sequestration of two biochemical controller species. The unbound amount of controller species captures the integral of the error between the current and the desired state of the system. However, implementing integral control inside bacterial cells using sequestration feedback has been challenging due to the controller molecules being degraded and diluted. Furthermore, integral control can only be achieved under stability conditions that not all sequestration feedback networks fulfill. In this work, we give guidelines for ensuring stability and good performance (small steady-state error) in sequestration feedback networks. Our guidelines provide simple tuning options to obtain a flexible and practical biological implementation of sequestration feedback control. Using tools and metrics from control theory, we pave the path for the systematic design of synthetic biological systems.		\|Abstract=Integral control is commonly used in mechanical and electrical systems to ensure perfect adaptation. A proposed design of integral control for synthetic biological systems employs the sequestration of two biochemical controller species. The unbound amount of controller species captures the integral of the error between the current and the desired state of the system. However, implementing integral control inside bacterial cells using sequestration feedback has been challenging due to the controller molecules being degraded and diluted. Furthermore, integral control can only be achieved under stability conditions that not all sequestration feedback networks fulfill. In this work, we give guidelines for ensuring stability and good performance (small steady-state error) in sequestration feedback networks. Our guidelines provide simple tuning options to obtain a flexible and practical biological implementation of sequestration feedback control. Using tools and metrics from control theory, we pave the path for the systematic design of synthetic biological systems.
	\|URL=https://www.biorxiv.org/content/biorxiv/early/2018/10/30/455493.full-text.pdf		\|URL=https://www.biorxiv.org/content/biorxiv/early/2018/10/30/455493.full-text.pdf
	\|Type=Journal ~~submission~~		\|Type=Journal paper
	\|ID=2018g		\|ID=2018g
	\|Tag=blom18-cellsys		\|Tag=blom18-cellsys
	\|Funding=DARPA BioCon		\|Funding=DARPA BioCon
	}}		}}

Murray at 15:47, 26 January 2019

2019-01-26T15:47:53Z

← Older revision		Revision as of 15:47, 26 January 2019
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	\|Title=Design Guidelines For Sequestration Feedback Networks		\|Title=Design Guidelines For Sequestration Feedback Networks
	\|Authors=Ania-Ariadna Baetica, Yoke Peng Leong, Noah Olsman, Richard M. Murray		\|Authors=Ania-Ariadna Baetica, Yoke Peng Leong, Noah Olsman, Richard M. Murray
	\|Source=Submitted, <i>Cell Systems<i> (Nov 2018)		\|Source=Submitted, <i>Cell Systems</i> (Nov 2018)
	\|Abstract=Integral control is commonly used in mechanical and electrical systems to ensure perfect adaptation. A proposed design of integral control for synthetic biological systems employs the sequestration of two biochemical controller species. The unbound amount of controller species captures the integral of the error between the current and the desired state of the system. However, implementing integral control inside bacterial cells using sequestration feedback has been challenging due to the controller molecules being degraded and diluted. Furthermore, integral control can only be achieved under stability conditions that not all sequestration feedback networks fulfill. In this work, we give guidelines for ensuring stability and good performance (small steady-state error) in sequestration feedback networks. Our guidelines provide simple tuning options to obtain a flexible and practical biological implementation of sequestration feedback control. Using tools and metrics from control theory, we pave the path for the systematic design of synthetic biological systems.		\|Abstract=Integral control is commonly used in mechanical and electrical systems to ensure perfect adaptation. A proposed design of integral control for synthetic biological systems employs the sequestration of two biochemical controller species. The unbound amount of controller species captures the integral of the error between the current and the desired state of the system. However, implementing integral control inside bacterial cells using sequestration feedback has been challenging due to the controller molecules being degraded and diluted. Furthermore, integral control can only be achieved under stability conditions that not all sequestration feedback networks fulfill. In this work, we give guidelines for ensuring stability and good performance (small steady-state error) in sequestration feedback networks. Our guidelines provide simple tuning options to obtain a flexible and practical biological implementation of sequestration feedback control. Using tools and metrics from control theory, we pave the path for the systematic design of synthetic biological systems.
	\|URL=https://www.biorxiv.org/content/biorxiv/early/2018/10/30/455493.full-text.pdf		\|URL=https://www.biorxiv.org/content/biorxiv/early/2018/10/30/455493.full-text.pdf

Murray: Created page with "{{Paper |Title=Design Guidelines For Sequestration Feedback Networks |Authors=Ania-Ariadna Baetica, Yoke Peng Leong, Noah Olsman, Richard M. Murray |Source=Submitted, Cell..."

2018-12-27T05:43:56Z

Created page with "{{Paper |Title=Design Guidelines For Sequestration Feedback Networks |Authors=Ania-Ariadna Baetica, Yoke Peng Leong, Noah Olsman, Richard M. Murray |Source=Submitted, <i>Cell..."

New page
{{Paper
|Title=Design Guidelines For Sequestration Feedback Networks
|Authors=Ania-Ariadna Baetica, Yoke Peng Leong, Noah Olsman, Richard M. Murray
|Source=Submitted, <i>Cell Systems<i> (Nov 2018)
|Abstract=Integral control is commonly used in mechanical and electrical systems to ensure perfect adaptation. A proposed design of integral control for synthetic biological systems employs the sequestration of two biochemical controller species. The unbound amount of controller species captures the integral of the error between the current and the desired state of the system. However, implementing integral control inside bacterial cells using sequestration feedback has been challenging due to the controller molecules being degraded and diluted. Furthermore, integral control can only be achieved under stability conditions that not all sequestration feedback networks fulfill. In this work, we give guidelines for ensuring stability and good performance (small steady-state error) in sequestration feedback networks. Our guidelines provide simple tuning options to obtain a flexible and practical biological implementation of sequestration feedback control. Using tools and metrics from control theory, we pave the path for the systematic design of synthetic biological systems.
|URL=https://www.biorxiv.org/content/biorxiv/early/2018/10/30/455493.full-text.pdf
|Type=Journal submission
|ID=2018g
|Tag=blom18-cellsys
|Funding=DARPA BioCon
}}