Design and Implementation of Multi-Component Synthetic Cells - Revision history

Murray: /* Objectives */

2025-06-14T16:37:21Z

Objectives

← Older revision		Revision as of 16:37, 14 June 2025
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	# Develop a design-oriented, computational framework enabling modeling, analysis, and design of multi-subsystem synthetic cells, incorporating core biomolecular processes, component-level dynamics, subsystem behaviors, and multi-subsystem interactions;		# Develop a design-oriented, computational framework enabling modeling, analysis, and design of multi-subsystem synthetic cells, incorporating core biomolecular processes, component-level dynamics, subsystem behaviors, and multi-subsystem interactions;
	# Implement and characterize a collection of biomolecular subsystems capable of providing robust and modular operations in synthetic cells;		# Implement and characterize a collection of biomolecular subsystems capable of providing robust and modular operations in synthetic cells;
	# Demonstrate a multi-component synthetic cell capable of artificial ~~chem- otaxis~~ using sensing of an environmental signal, decision-making based on the concentration of the environ- mental signal, and locomotion using a proto-flagellar motor or other similar mechanism.		# Demonstrate a multi-component synthetic cell capable of artificial chemotaxis using sensing of an environmental signal, decision-making based on the concentration of the environ- mental signal, and locomotion using a proto-flagellar motor or other similar mechanism.

	=== References ===		=== References ===

Murray at 16:36, 14 June 2025

2025-06-14T16:36:47Z

← Older revision		Revision as of 16:36, 14 June 2025
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	\|Reporting requirements=Annual report		\|Reporting requirements=Annual report
	\|Project ID=ICB Synthetic Cell		\|Project ID=ICB Synthetic Cell
	\|ack=This research is supported by the Institute for Collaborative Biotechnologies through cooperative agreement ~~TBD~~ from the U.S. Army Research Office. The content of the information on this page does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred.		\|ack=This research is supported by the Institute for Collaborative Biotechnologies through cooperative agreement W911NF-19-2-0026 from the U.S. Army Research Office. The content of the information on this page does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred.
	}}		}}

Murray at 02:56, 26 March 2025

2025-03-26T02:56:23Z

← Older revision		Revision as of 02:56, 26 March 2025
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	\|Title=Design and Implementation of Multi-Component Synthetic Cells		\|Title=Design and Implementation of Multi-Component Synthetic Cells
	\|Agency=ARO/ICB		\|Agency=ARO/ICB
	\|Grant number=~~TBD~~		\|Grant number=W911NF-19-2-0026
	\|Start date=1 Dec 2023		\|Start date=1 Dec 2023
	\|End date=30 Nov 2026		\|End date=30 Nov 2026

Murray at 05:15, 6 October 2024

2024-10-06T05:15:20Z

← Older revision		Revision as of 05:15, 6 October 2024
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	[[Category:Active projects]]		[[Category:Active projects]]
	[[Category:Biocircuits projects]]		[[Category:Biocircuits projects]]

	{{Project		{{Project
	\|Title=Design and Implementation of Multi-Component Synthetic Cells		\|Title=Design and Implementation of Multi-Component Synthetic Cells
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	\|Support summary=1 graduate student, part-time technician		\|Support summary=1 graduate student, part-time technician
	\|Reporting requirements=Annual report		\|Reporting requirements=Annual report
	\|Project ID=~~ICB24-syncell~~		\|Project ID=ICB Synthetic Cell
	\|ack=This research is supported by the Institute for Collaborative Biotechnologies through cooperative agreement TBD from the U.S. Army Research Office. The content of the information on this page does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred.		\|ack=This research is supported by the Institute for Collaborative Biotechnologies through cooperative agreement TBD from the U.S. Army Research Office. The content of the information on this page does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred.
	}}		}}

Murray: /* Objectives */

2024-01-15T20:14:53Z

Objectives

← Older revision		Revision as of 20:14, 15 January 2024
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	=== Objectives ===		=== Objectives ===
	[[Image:~~project~~-~~name~~.png\|right\|400px]]		[[Image:ICB24-syncell.png\|right\|400px]]
	The objectives for this project are to:		The objectives for this project are to:
	# Develop a design-oriented, computational framework enabling modeling, analysis, and design of multi-subsystem synthetic cells, incorporating core biomolecular processes, component-level dynamics, subsystem behaviors, and multi-subsystem interactions;		# Develop a design-oriented, computational framework enabling modeling, analysis, and design of multi-subsystem synthetic cells, incorporating core biomolecular processes, component-level dynamics, subsystem behaviors, and multi-subsystem interactions;

Murray: /* Objectives */

2024-01-15T20:14:24Z

Objectives

← Older revision		Revision as of 20:14, 15 January 2024
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	[[Image:project-name.png\|right\|400px]]		[[Image:project-name.png\|right\|400px]]
	The objectives for this project are to:		The objectives for this project are to:
	# ~~dDevelop~~ a design-oriented, computational framework enabling modeling, analysis, and design of multi-subsystem synthetic cells, incorporating core biomolecular processes, component-level dynamics, subsystem behaviors, and multi-subsystem interactions;		# Develop a design-oriented, computational framework enabling modeling, analysis, and design of multi-subsystem synthetic cells, incorporating core biomolecular processes, component-level dynamics, subsystem behaviors, and multi-subsystem interactions;
	# Implement and characterize a collection of biomolecular subsystems capable of providing robust and modular operations in synthetic cells;		# Implement and characterize a collection of biomolecular subsystems capable of providing robust and modular operations in synthetic cells;
	# Demonstrate a multi-component synthetic cell capable of artificial chem- otaxis using sensing of an environmental signal, decision-making based on the concentration of the environ- mental signal, and locomotion using a proto-flagellar motor or other similar mechanism.		# Demonstrate a multi-component synthetic cell capable of artificial chem- otaxis using sensing of an environmental signal, decision-making based on the concentration of the environ- mental signal, and locomotion using a proto-flagellar motor or other similar mechanism.

Murray: /* Objectives */

2024-01-15T20:14:14Z

Objectives

← Older revision		Revision as of 20:14, 15 January 2024
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	[[Image:project-name.png\|right\|400px]]		[[Image:project-name.png\|right\|400px]]
	The objectives for this project are to:		The objectives for this project are to:
	~~1. develop~~ a design-oriented, computational framework enabling modeling, analysis, and design of multi-subsystem synthetic cells, incorporating core biomolecular processes, component-level dynamics, subsystem behaviors, and multi-subsystem interactions;		# dDevelop a design-oriented, computational framework enabling modeling, analysis, and design of multi-subsystem synthetic cells, incorporating core biomolecular processes, component-level dynamics, subsystem behaviors, and multi-subsystem interactions;
	~~2. implement~~ and characterize a collection of biomolecular subsystems capable of providing robust and modular operations in synthetic cells;		# Implement and characterize a collection of biomolecular subsystems capable of providing robust and modular operations in synthetic cells;
	~~3. demonstrate~~ a multi-component synthetic cell capable of artificial chem- otaxis using sensing of an environmental signal, decision-making based on the concentration of the environ- mental signal, and locomotion using a proto-flagellar motor or other similar mechanism.		# Demonstrate a multi-component synthetic cell capable of artificial chem- otaxis using sensing of an environmental signal, decision-making based on the concentration of the environ- mental signal, and locomotion using a proto-flagellar motor or other similar mechanism.

	=== References ===		=== References ===

Murray at 20:13, 15 January 2024

2024-01-15T20:13:44Z

← Older revision		Revision as of 20:13, 15 January 2024
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	{{righttoc}}		{{righttoc}}
	~~Project description (typically about~~ a ~~paragraph)~~		The long-term goal of this research is to create genetically programmed synthetic cells consisting of multiple subsystems operating in an integrated fashion. Unlike more traditional synthetic biology approaches, synthetic cells are non-living: they make use of genetic elements provided by biology, but they do not replicate, mutate, or evolve. Applica- tions range from synthesis of bio-compatible materials, to environmental monitoring and remediation, to self-assembly of complex multi-cellular machines. Pursuing this goal requires fundamental research in biological engineering, aimed at moving from creation of clever biomolecular devices to systematic specification, design, integration, and testing of circuits, subsystems, cells, and multi-component systems.

			We propose to develop and demonstrate the key design tools, molecular components, and system-level architecture for synthetic cells. While we do not anticipate that a single project will lead to a functioning synthetic cell in a 3–5-year time, we believe that it will be possible implement and integrate a variety of subsystems that establish the feasibility of synthetic cells and serve as a starting point for a larger effort.

	{\| cellpadding=0 cellspacing=0 width=80%		{\| cellpadding=0 cellspacing=0 width=80%
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	=== Objectives ===		=== Objectives ===
	[[Image:project-name.png\|right\|400px]]		[[Image:project-name.png\|right\|400px]]
	~~Description~~ of the ~~main objectives~~ of the ~~project~~		The objectives for this project are to:
			1. develop a design-oriented, computational framework enabling modeling, analysis, and design of multi-subsystem synthetic cells, incorporating core biomolecular processes, component-level dynamics, subsystem behaviors, and multi-subsystem interactions;
			2. implement and characterize a collection of biomolecular subsystems capable of providing robust and modular operations in synthetic cells;
			3. demonstrate a multi-component synthetic cell capable of artificial chem- otaxis using sensing of an environmental signal, decision-making based on the concentration of the environ- mental signal, and locomotion using a proto-flagellar motor or other similar mechanism.

	=== References ===		=== References ===
	{{project paper list}}		{{project paper list}}

	[[Category:~~Pending project~~]]		[[Category:Active projects]]
	~~<!--~~ [[Category:~~Subgroup~~ projects]] ~~-->~~		[[Category:Biocircuits projects]]

	{{Project		{{Project
	\|Title=Design and Implementation of Multi-Component Synthetic Cells		\|Title=Design and Implementation of Multi-Component Synthetic Cells

Murray at 20:10, 15 January 2024

2024-01-15T20:10:40Z

← Older revision		Revision as of 20:10, 15 January 2024
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	[[Category:Pending project]]		[[Category:Pending project]]
	<!-- [[Category:Subgroup projects]] -->		<!-- [[Category:Subgroup projects]] -->

	{{Project		{{Project
	\|Title=Design and Implementation of Multi-Component Synthetic Cells		\|Title=Design and Implementation of Multi-Component Synthetic Cells
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	\|Grant number=TBD		\|Grant number=TBD
	\|Start date=1 Dec 2023		\|Start date=1 Dec 2023
	\|End date=30 Nov ~~2028~~		\|End date=30 Nov 2026
	\|Support summary=1 graduate student, part-time technician		\|Support summary=1 graduate student, part-time technician
	\|Reporting requirements=Annual report		\|Reporting requirements=Annual report
	\|Project ID=ICB24-syncell		\|Project ID=ICB24-syncell
			\|ack=This research is supported by the Institute for Collaborative Biotechnologies through cooperative agreement TBD from the U.S. Army Research Office. The content of the information on this page does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred.
	}}		}}

Murray: Created page with "{{subst:project boilerplate}} {{Project |Title=Design and Implementation of Multi-Component Synthetic Cells |Agency=ARO/ICB |Grant number=TBD |Start date=1 Dec 2023 |End date=30 Nov 2028 |Support summary=1 graduate student, part-time technician |Reporting requirements=Annual report |Project ID=ICB24-syncell }}"

2024-01-15T20:09:12Z

Created page with "{{subst:project boilerplate}} {{Project |Title=Design and Implementation of Multi-Component Synthetic Cells |Agency=ARO/ICB |Grant number=TBD |Start date=1 Dec 2023 |End date=30 Nov 2028 |Support summary=1 graduate student, part-time technician |Reporting requirements=Annual report |Project ID=ICB24-syncell }}"

New page

{{righttoc}}
Project description (typically about a paragraph)

{| cellpadding=0 cellspacing=0 width=80%
|- valign=top
|
Current participants:
{{project current participants}}
Additional participants:
{{project additional participants}}
|
Collaborators:

Past participants:
{{project past participants}}
|}

=== Objectives ===
[[Image:project-name.png|right|400px]]
Description of the main objectives of the project

=== References ===
{{project paper list}}

[[Category:Pending project]]


{{Project
|Title=Design and Implementation of Multi-Component Synthetic Cells
|Agency=ARO/ICB
|Grant number=TBD
|Start date=1 Dec 2023
|End date=30 Nov 2028
|Support summary=1 graduate student, part-time technician
|Reporting requirements=Annual report
|Project ID=ICB24-syncell
}}